Borja
Country: Spain
Languages: English, Spanish, Catalan
Research interests: intrinsically disordered proteins, NMR methodology, drug discovery, solvent effects, liquid-liquid phase separation
Research overview: I am interested in the study of intrinsically disordered proteins (IDPs) using biophysical methods, mainly NMR spectroscopy. I am particularly interested in the development of tailored NMR experiments for challenging systems. My current research focuses on the understanding of the conformational propensities of IDPs and how these preferential structural elements can be used for the therapeutic target of these targets.
Research highlights:
(2020) Mateos, Borja, Marco Sealey‐Cardona, Katja Balazs, Judith Konrat, Guenther Staffler, and Robert Konrat. 2020. “NMR Characterization of Surface Receptor Protein Interactions in Live Cells Using Methylcellulose Hydrogels.” Angewandte Chemie International Edition 59 (10): 3886–90. https://doi.org/10.1002/anie.201913585.
(2020) Mateos, Borja, Clara Conrad-Billroth, Marco Schiavina, Andreas Beier, Georg Kontaxis, Robert Konrat, Isabella C. Felli, and Roberta Pierattelli. 2020. “The Ambivalent Role of Proline Residues in an Intrinsically Disordered Protein: From Disorder Promoters to Compaction Facilitators.” Journal of Molecular Biology 432 (9): 3093–3111. https://doi.org/10.1016/j.jmb.2019.11.015.
(2021) Mateos, Borja, Ganeko Bernardo-Seisdedos, Valentin Dietrich, Nicanor Zalba, Gabriel Ortega, Francesca Peccati, Gonzalo Jiménez-Osés, Robert Konrat, Martin Tollinger, and Oscar Millet. 2021. “Cosolute modulation of protein oligomerization reactions in the homeostatic timescale” Biophysical journal 120 (10): 2067-2077. https://doi.org/10.1016/j.bpj.2021.03.020