Ruth
Country: UK
Languages: English
Research interests: regulation, chaperones, dynamics, NMR, systems
Research overview: I use a combination of biochemical and structural techniques to characterise client-cochaperone complexes in the Hsp90 chaperone system. We want to understand the conformational transitions in recognition, binding and processing of hsp90 clients and how this ties to selectivity.
Research group page:
http://www.sussex.ac.uk/lifesci/pearllab/research/chaperones
Research highlights:
(2019) Characterising side chains in large proteins by protonless 13C-detected NMR spectroscopy, Ruth B. Pritchard; D. Flemming Hansen. Nature Communications 10:1747. DOI: 10.1038/s41467-019-09743-4
(2019) Importance of the Force Field Choice in Capturing Functionally Relevant Dynamics in the von Willebrand Factor, Antonija Kuzmanic, Ruth B. Pritchard, D. Flemming Hansen Francesco L. Gervasio. J. Phys. Chem. Lett. 10(8): 1928–1934 DOI: 10.1021/acs.jpclett.9b00517
(2019) Determining isoleucine side-chain rotamer-sampling in proteins from 13C chemical shift, Lucas Siemons, Boran Uluca-Yazgi, Ruth B. Pritchard, Stephen McCarthy, Henrike Heise and D. Flemming Hansen. Chem. Commun., 55, 14107-14110 DOI: 10.1039/c9cc06496f