Structural insights into Amelotin oligomerization by pressure-jump NMR spectroscopy

Sai Chiliveri, National Institutes of Health (USA)


Amelotin plays a crucial role in the hydroxyapatite mineralization of dental enamel. Due to their dynamic and heterogeneous nature, large oligomeric species formed by Amelotin are not amenable to structural studies at the residue-specific level. Here, we present new pressure-jump NMR methods for probing the structure of oligomeric species. Secondary and tertiary structure information on the oligomers obtained from 13C chemical shifts and 1H-1H nuclear Overhauser enhancements (NOE) will be demonstrated.

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